Brother of Elizabeth Rodriguez, Tina Rodriguez, David Rodriguez, Rebecca Rodriguez, Patricia Vonne, and Angela Lanza. Cousin of Álvaro Rodríguez & actor Danny Trejo.
Went to St. Anthony's High School.
Studied at St. Anthony's University, The University of Texas at Austin.
He earned most of the $7000 it cost to make El Mariachi (1992) by subjecting himself to experimental drug studies. One of the experimental drugs that was tested on Rodriguez was a "speed healer." He has two divots in his arms as a result of the removed sample.
In April of 1996, headed the list of "25 Most Powerful Hispanics in Hollywood", published by Hispanic Magazine.