Hussain is married to Dr. Rakhshanda Hussain, a professor of psychology at the University of Karachi. They have three children, two daughters and one son : Tazeen,the eldest daughter, was a television actress before quitting after her wedding, the younger daughter, Roohaina, has a few television plays to her credit, while the son is working at a multinational company after doing a MBA degree and is interested in film-making.
In 2012, he is a faculty member at the National Academy of Performing Arts (NAPA) in Karachi where he teaches acting and serves as a member of the governing body at the Karachi Arts Council and an ambassador of I Am Karachi. He has also been affiliated with Pakistan Electronic Media Regulatory Authority (a PEMRA member) and the National Book Foundation of Pakistan (an ambassador).
In February 2012, in an interview to a major English-language newspaper of Pakistan, Talat Hussain revealed that he caught a skin allergy in 2010. This skin allergy developed complications due to wrong treatment by a local cosmetologist. "I couldn't even talk properly, let alone walk or sit after the treatment." His hands trembled and it was difficult for him to hold a teacup and light his cigarette back in 2012.