Missi Pyle was born on November 16, 1972 as Andrea Kay Pyle in Houston, Texas, and was raised in Memphis, Tennessee. The daughter of Linda and Frank Pyle, she has four older siblings, sisters Debbie and Julie, and brothers Sam and Paul. Pyle attended the North Carolina School of the Arts and graduated in 1995. Since then, Pyle has had a significant career in many films and television series. She has also established in parallel a singing career as a member of the band Smith & Pyle with actress Shawnee Smith.