Directed the 2003 and 2004 WB Image Campaigns for popular shows such as Gilmore Girls (2000), One Tree Hill (2003), 7th Heaven (1996), etc... Some of the WB stars he directed included David Boreanaz, Tom Welling, Kristin Kreuk, Michael Rosenbaum, Jamie Kennedy, James Marsters, Rose McGowan, Allison Mack, Chad Michael Murray, James Lafferty, Beverley Mitchell and Reba McEntire.
The part of Chris Pierce on American Dreams (2002) was written specifically for him after he met with the show's creators.
He attended El Modena High School in Orange, CA. He graduated in 1995.
Made his debut in The Fresh Prince of Bel-Air: Bourgie Sings the Blues (1995).
Boyfriend of Gilmore Girls (2000) co-star Alexis Bledel from 2002 to 2006.
His father is of Italian (Sicilian) descent. His mother is of English and Scottish ancestry; half of her family is most recently from the American South, while the other half is composed of recent immigrants from England and Scotland (by way of Canada).
He has a '67 Chevelle Super Sport named "Evelyn".
Milo and Heroes (2006) co-star Adrian Pasdar auditioned for roles in the proposed Gilmore Girls spin-off where Milo was to be the son of Pasdar's character. As there is only twelve years difference between them, the casting director said they would be better off playing brothers. Eight years later, they were playing brothers Peter (Milo) and Nathan (Pasdar) Petrelli in Heroes (2006).
Started a production company named DiVide Pictures.
Similar to his fellow Gilmore Girls (2000) cast, also donates to the Pediatric Brain Tumor Foundation, one of his favorite charities.
His favorite book is The Long Walk (Stephen King, firmed with the pseudonym of Richard Bachman).
Close friend of Sophia Bush.
His Favorite Bands are The Strokes, Deftones, A Tribe Called Quest, The Hives.
Starred in a season three episode of Gilmore Girls (2000), which was the backdoor pilot for a California-set spin-off titled "Windward Circle", that was to have starred Ventimiglia, Sherilyn Fenn and Rob Estes. The network dropped the project citing cost issues due to filming on location in Venice, California.
Is the ex-boyfriend of Heroes (2006)co-star Hayden Panettiere; the press dubbed them "Haylo". 
Ventimiglia took a United Service Organization (USO) tour from July 6 to 12, 2008 in support of American troops in Kuwait, Iraq and Afghanistan.
Close friend of Heroes (2006) co-star Adrian Pasdar.
Has two older sisters, Leslie and Laurel, born circa 1973 and 1975.
Starring in Fergie's video for "Big Girls Don't Cry". [June 2007]
His self-described 'crooked mouth' is a result of dead nerves, which cause the left side of his mouth to remain immobile.
Nominated for the 2018 Emmy Award in the Lead Actor in a Drama Series category for his role as Jack Pearson in This Is Us (2016), but lost to Matthew Rhys from The Americans (2013).