Born to James Ronald Winstead and his wife Betty Lou Knight.
Enjoys cooking, dancing, and singing.
She is a second cousin, three times removed, of actress Ava Gardner, through her paternal grandfather, Ambler William Winstead. Mary Elizabeth's paternal great-great-great-great-grandparents, William Gardner and Cynthia Eliza Batts, were also Ava's paternal great-grandparents.
In 2007 she was chosen by Empire magazine as one of the 100 Sexiest Stars in film history (#100).
Ranked #10 on Maxim's "Hottest Women of Horror Movies" list.
Ranked #88 in FHM's 100 Sexiest Women of 2009.
In 2009 she was chosen by Empire magazine as one of the 20 "young, talented, and really happening right now".
Was featured in "The Women of GQ".
Named as Hottest Girls of Comic-Con 2010.
Ranked #17 out of 101 for Men's Health 'Hottest Women of 2011'.
Favorite movies include Sunset Blvd. (1950), and Fargo (1996). Being a huge horror movie fan her favorites are Rosemary's Baby (1968), Black Christmas (1974), Alien (1979), and The Shining (1980).