Grand-daughter of Indian freedom fighter, lawyer, and former Justice Rajni Patel, Amisha, a Gemini, was born in Bombay's Breach Candy Hospital. Her younger brother Ashmit Patel is also a Bollywood film actor and her name is a blend of the first three letters of her father's name Amit and the last three letters of her mother's name Asha.

She studied at the Cathedral and John Connon High School in Bombay, and went on to obtain a degree in Economics from Tufts University in Medford, Massachusetts, U.S.A. After graduation she worked for a Finance company and also modeled on the side.

She has studied Bharat Natyam dance form since the age of five, and had acted in several plays in Satyadev Dubey's Theatre including a play titled 'Neelam'.

She did not have any plans of being an actress, but when Amit's friend, film-maker and actor, Rakesh Roshan, met her during a family lunch, he offered her the lead role in 'Kaho Naa... Pyaar Hai'. Amisha accepted the offer, the movie went on to become a blockbuster, and made her a star overnight.

She went on to star in a number of films and her most notable works include 'Gadar: Ek Prem Katha', 'Humraaz', 'Yeh Hai Jalwa', 'Mangal Pandey', 'Honeymoon Travels Pvt. Ltd.', 'Bhool Bhulaiyaa', 'Thoda Pyaar Thoda Magic', and 'Race 2'.

She has also acted in several South Indian films.

Amisha has been the recipient of four awards for her performances in 'Kaho Naa... Pyaar Hai', and 'Gadar: Ek Prem Katha'.

She has co-starred with Akshaye Khanna, Sunny Deol, Akshay Kumar, Bobby Deol, Sanjay Dutt, Aftab Shivdasani, Hrithik Roshan, Arjun Rampal amongst others.

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Trivia

Won gold medal for an Economics paper at her university.
Obtained Biogenetic Engineering degree in the United States.
Granddaughter of barrister politican, Rajni Patel.
Economic graduate from Tufts University, Boston
Daughter of Asha Patel and sister of Ashmit Patel
Attended Tufts University in Medford, Massachusetts. Studied Economics and graduated as part of the class of 1997.
Turned down Bipasha Basu's role in Jism (2003).
Dropped out of the role of Bhoomika Chawla in In Your Name (2003) due to scheduling conflicts.
Her favorite movies are From Doom Till Doom (1988), Dilwale Dulhania Le Jayenge (1995), Umrao Jaan (1981), Chandni (1989) and Pretty Woman (1990).
Was considered for the role of Bindiya in Billu (2009) but it was then decided she looked too young to play a mother of two.

[on item numbers] I don't mind an item number like "Kajra Re" from Bunty Aur Babli (2005), it's done well and the song seems like a whole lot of fun. But if I did a "Khallas," my career would also be Khallas with it!
[on Hrithik Roshan's and Sussanne Roshan's new born child, Hrehaan] We were children together... now the child I knew, has a child. Such a long journey... in such a short time, now they embark on another journey. A journey of parenthood. I wish them all the best. Sussanne and Hrithik are beautiful people and now the most beautiful thing has happened to them.
I would never deny the importance of the media, but I wouldn't go out of the way to splash my pictures all over town. I'd rather let my work do the talking.
Films were never on my agenda, may be it was written in my destiny. And since I am here, I would like to give it my best try.
No one wants to touch you, if you don't have a film background. Which is why outsiders like me have to work doubly hard to get noticed.